Over the years, research has proposed several explanations for why people develop SAD. One key factor involves the neurotransmitter serotonin, which plays a central role in regulating mood (Melrose, 2015). Studies have found that individuals with seasonal affective disorder may have difficulty regulating serotonin levels (McMahon et al., 2014).
Another important component is the protein SERT, which helps transport serotonin from the synaptic cleft back to the presynaptic neuron. Higher levels of SERT can reduce serotonin activity, contributing to depressive symptoms.
McMahon and colleagues (2014) found that people with SAD had approximately 5% higher SERT levels during the winter months compared to summer, which may help explain seasonal mood changes.
Additionally, exposure to sunlight is also another factor in the disorder. Sunlight contains vitamin D, which helps in serotonin activity; therefore, vitamin D deficiency in the winter months can cause significant depressive symptoms.
Research has shown that light therapy can be just as effective as antidepressant medication. For example, a study by Lam and colleagues (2006) compared the two treatments in individuals with seasonal affective disorder and found no significant difference in outcomes.
Additionally, because low vitamin D levels are associated with the disorder, taking vitamin D supplements before the winter months may help prevent depressive symptoms.
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Lam, R. W., Levitt, A. J., Levitan, R. D., Enns, M. W., Morehouse, R., Michalak, E. E., & Tam, E. M. (2006). The CAN-SAD Study: A randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorder. American Journal of Psychiatry, 163(5), 805–812. https://doi.org/10.1176/ajp.2006.163.5.805
Lewy, A. J., Lefler, B. J., Emens, J. S., & Bauer, V. K. (2006). The circadian basis of winter depression. Proceedings of the National Academy of Sciences, 103(19), 7414–7419. https://doi.org/10.1073/pnas.0602425103
McMahon, B., Andersen, S., Madsen, M., Hjordt, L., Hageman, I., Dam, H., Svarer, C., Da Cunha-Bang, S., Barré, W., Madsen, J., Hasholt, L., Frokjaer, V., & Knudsen, G. (2014). P.1.i.037 Patients with seasonal affective disorder show seasonal fluctuations in their cerebral serotonin transporter binding. European Neuropsychopharmacology, 24, S319. https://doi.org/10.1016/s0924-977x(14)70506-1
Melrose, S. (2015). Seasonal Affective Disorder: An Overview of assessment and Treatment Approaches. Depression Research and Treatment, 2015, 1–6. https://doi.org/10.1155/2015/178564
Seasonal affective disorder. (n.d.). National Institute of Mental Health (NIMH). https://www.nimh.nih.gov/health/publications/seasonal-affective-disorder#part_6692